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KMID : 0357920100440030284
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Korean Journal of Pathology
2010 Volume.44 No. 3 p.284 ~ p.294
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Immunohistochemical Array for Clear Cell Type Mucoepidermoid Carcinoma
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Kim Yeon-Sook
Lee Sang-Shin
Song Ji-Yong
Kim Eun-Cheol
Lee Suk-Keun
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Abstract
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Background: The protein expression profile of clear cell type mucoepidermoid carcinoma (MEC) is not well known.
Methods: We examined a case of clear cell type MEC by immunohistochemical (IHC) array using 59 antibodies against oncoproteins, proliferation-related proteins, apoptosis-related proteins, growth factor-related proteins, angiogenesis-related proteins, and matrix proteins.
Results: MEC tumor cells showed 40 to 60% more expression of BCL-2 and cyclin-dependent kinase 4 than normal gingival tissue, and 20-40% more expression of BCL-2-associated agonist of cell death, deleted in malignant brain tumors 1, E-cadherin, eIF5A, hypoxia-inducible factor, vimentin, and Wnt-1. Expression of other proteins, including p53, epidermal growth factor receptor, proliferating cell nuclear antigen, survivin, carcinoembryonic antigen, β-catenin, poly-ADP ribose-polymerase, etc. were relatively weak in MEC tumor cells.
Conclusions: The IHC array for our MEC contained strong oncogenic signals involving Wnt-1/adenomatous polyposis coli, tumor necrosis factor a/signal transducer and activator of transcription 3/BCL-2, and pAKT pathways, signals that could result in the prolonged survival of clear tumor cells.
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KEYWORD
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Oncogenes, Immunohistochemistry, Array
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